Error-Tolerant Biochemical Sample Preparation with Microfluidic Lab-on-Chip

Sudip Poddar, Bhargab B. Bhattacharya

• Éditeur: CRC Press
• Année: 2022
• ISBN:
  9781000612738
• Édition: 1
• Sujet: Technologie et ingénierie
• Sous-sujet: Ingénierie de la chimie et de la biochimie

Microfluidic biochips have gained prominence due to their versatile applications to biochemistry and health-care domains such as point-of-care clinical diagnosis of tropical and cardiovascular diseases, cancer, diabetes, toxicity analysis, and for the mitigation of the global HIV crisis, among others. Microfluidic Lab-on-Chips (LoCs) offer a convenient platform for emulating various fluidic operations in an automated fashion. However, because of the inherent uncertainty of fluidic operations, the outcome of biochemical experiments performed on-chip can be erroneous even if the chip is tested a priori and deemed to be defect-free. This book focuses on the issues encountered in reliable sample preparation with digital microfluidic biochips (DMFBs), particularly in an error-prone environment. It presents state-of-the-art error management techniques and underlying algorithmic challenges along with their comparative discussions.

• Describes a comprehensive framework for designing a robust and error-tolerant biomedical system which will help in migrating from cumbersome medical laboratory tasks to small-sized LOC-based systems

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• Presents a comparative study on current error-tolerant strategies for robust sample preparation using DMFBs and reports on efficient algorithms for error-tolerant sample dilution using these devices

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• Illustrates how algorithmic engineering, cyber-physical tools, and software techniques are helpful in implementing fault tolerance

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• Covers the challenges associated with design automation for biochemical sample preparation

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• Teaches how to implement biochemical protocols using software-controlled microfluidic biochips

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Interdisciplinary in its coverage, this reference is written for practitioners and researchers in biochemical, biomedical, electrical, computer, and mechanical engineering, especially those involved in LOC or bio-MEMS design.