The Microbiome and the Brain

David Perlmutter

• Publisher: CRC Press
• Year: 2019
• ISBN:
  9781351235686
• Edition: 1
• Topic: Medicine
• Subtopic: Alternative & Complementary Medicine

Brain related disorders are among the most challenging health issues of our time. The development of effective therapeutic and preventive strategies for these disorders relies on a comprehensive understanding of the underlying causative mechanisms. And, until recently, these mechanisms have remained somewhat elusive.

The newly discovered pivotal role of the intestinal microbiome in brain health, functionality, and resistance to disease is revolutionizing neuroscience. The Microbiome and the Brain, through the contributions of some of the most forward thinking researchers and clinicians in the field, comprehensively reveals the leading edge of our understanding of the fundamental role of gut microbes and their metabolites in a wide array of seemingly diverse brain issues including Alzheimer's disease, autism, multiple sclerosis, and mood disorders. In addition, mechanisms defining these relationships are explored along with a presentation of the state-of-the-art as it relates to interpretation of relevant laboratory assessments. Finally, novel therapeutic opportunities, derived from this exciting science are presented.

Readers will learn:

• The highly validated relationship between alterations of gut microbes and their metabolites, and risk for Alzheimer's disease.

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• The important link between autism and intestinal dysbiosis.

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• Appropriate interpretation of available laboratory assessments of the intestinal microbiome.

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• The potential role of fecal microbial transplant in neurological diseases.

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• The influence of diet and other lifestyle choices on the microbiome as it relates to brain health and functionality.

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Table of contents

• Cover
• Half-Title
• Title
• Copyright
• Contents
• Editor
• List of Contributors
• Introduction
• Chapter 1 Assessing the Microbiome—Current and Future Technologies and Applications
• Chapter 2 The Microbiome – Role in Personalized Medicine
• Chapter 3 Immune Response to Microbial Toxins in Inflammatory and Neurodegenerative Disorders
• Chapter 4 The Microbiome—Its Role in Neuroinflammation
• Chapter 5 Nutrition and the Microbiome—Implications for Autism Spectrum Disorder
• Chapter 6 Alzheimer’s Disease, the Microbiome, and 21st Century Medicine
• Chapter 7 Microbial Involvement in Alzheimer’s Disease
• Chapter 8 The Role of the Microbiome in Mood
• Chapter 9 The Microbiome in Multiple Sclerosis
• Chapter 10 Bacteriophage Involvement in Neurodegenerative Diseases
• Chapter 11 The Role of Fecal Microbiota Transplantation in Neurological Diseases
• Chapter 12 Lifestyle Influences on the Microbiome
• Index