The Transformed Cell

Ivan Cameron, Ivan Cameron

• Publisher: Academic Press
• Year: 1981
• ISBN:
  9780323162968
• Topic: Biological Sciences
• Subtopic: Botany
• Index: Biological Sciences

The Transformed Cell deals with many of the differences that may exist between transformed cells and their normal counterparts. Topics covered range from malignancy and the cell surface to cell cycle regulation in normal and transformed cells; phenotypic expression of malignant transformation and its relationship to energy metabolism; and virus-induced transformation. The involvement of cyclic nucleotides in transformation is also discussed, together with intracellular pH and growth control in eukaryotic cells. This book is comprised of 12 chapters and begins with a brief description of terminology and basic concepts relating to cancer cells, as well as some comments on tumorigenicity and cell transformation. The next two chapters explore the evidence for and against the possible correlation of in vivo tumorigenicity to in vitro changes in the cytoskeletal system; anchorage-dependent growth; plasminogen activator production; agglutinability by lectins; and cell surface and plasma membrane properties. The regulation of cell proliferation and the relationships between ion movement and energy metabolism in normal and transformed cells are then examined, along with the transformation of normal cells by infection with new genetic material from tumor viruses. The remaining chapters focus on selected cellular properties that have been purported to differ between the normal and transformed cell, with particular reference to cyclic nucleotides; polyamine metabolism; cell viscosity; mobility of cellular water; intracellular pH; and element concentration. This monograph will be of interest to biologists and medical practitioners devoted to understanding cancer cell biology and cancer therapy.

Table of contents

• Front Cover
• The Transformed Cell
• Copyright Page
• Table of Contents
• List of Contributors
• Preface
• Chapter 1. The Transformed Cell: Some Introductory Comments
• Chapter 2. Malignant Transformation: In Vivo Methods and in Vitro Correlates
• Chapter 3. Malignancy and the Cell Surface
• Chapter 4. Cell Cycle Regulation in Normal and Transformed Cells
• Chapter 5. Phenotypic Expression of Malignant Transformation and Its Relationship to Energy Metabolism
• Chatper 6. Virus-Induced Transformation
• Chapter 7. Involvement of Cyclic Nucleotides in Transformation
• Chapter 8. Role of Polyamines in the Regulation of the Cell Cycle in Normal and Transformed Mammalian Cells
• Chapter 9. Distinction of Normal, Preneoplastic, and Neoplastic Mouse Mammary Cells and Tissues by Nuclear Magnetic Resonance Techniques
• Chapter 10. Spin Label Viscosity Studies of Mammalian Cell Cytoplasm
• Chapter 11. Intracellular pH and Growth Control in Eukaryotic Cells
• Chapter 12. Intracellular Sodium and Growth Control: A Comparison of Normal and Transformed Cells
• Index