Antibody Engineering
eBook - PDF

Antibody Engineering

Thomas Böldicke

  1. 312 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Antibody Engineering

Thomas Böldicke

Book details
Table of contents
Citations

About This Book

Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display methods, humanization by chain shuffling, affinity maturation techniques, de novo synthesis of antibody genes, colony assays for library screening, construction of scFvs from hybridomas, and purification of monoclonal antibodies by exclusion chromatography. In addition, other topics that are discussed in this book are application and mechanism of single domain antibodies, structural diversity of antibodies, immune-mediated skin reactions induced by TNF-alpha recombinant antibodies, and bioinformatic approaches to select pathogen-derived peptide sequences for antibody targets.

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Information

Publisher
IntechOpen
Year
2018
ISBN
9789535139751
Topic
Medicine
Subtopic
Genetics in Medicine

Table of contents

    Citation styles for Antibody Engineering

    APA 6 Citation

    [author missing]. (2018). Antibody Engineering ([edition missing]). IntechOpen. Retrieved from https://www.perlego.com/book/2024914/antibody-engineering-pdf (Original work published 2018)

    Chicago Citation

    [author missing]. (2018) 2018. Antibody Engineering. [Edition missing]. IntechOpen. https://www.perlego.com/book/2024914/antibody-engineering-pdf.

    Harvard Citation

    [author missing] (2018) Antibody Engineering. [edition missing]. IntechOpen. Available at: https://www.perlego.com/book/2024914/antibody-engineering-pdf (Accessed: 25 September 2021).

    MLA 7 Citation

    [author missing]. Antibody Engineering. [edition missing]. IntechOpen, 2018. Web. 25 Sept. 2021.