Basic and clinical aspects of immunity to insulin

Proceedings, International Workshop, September 28–October 1, 1980, Konstanz

Klaus Keck, P. Erb

• Publisher: De Gruyter
• Year: 2019
• ISBN:
  9783111518053
• Edition: 1
• Topic: Medicine
• Subtopic: Medical Theory, Practice & Reference

Table of contents

• PREFACE
• LIST OF PARTICIPANTS
• CONTENTS
• SECTION I. BASIC ASPECTS OF IMMUNITY TO INSULIN
• Introduction: Insulin as a tool for the study of immunological problems
• Genetic control of the immune response to insulin
• Analysis of the in vitro induction of insulin-specific helper T cells
• Immunogenic determinants of insulin: Synthesis and immunogenicity of the A-chain loop peptides of beef insulin
• Analysis of H-2 gene regulation of the response of T lymphocytes to insulin using synthetic antigenic determinants and anti-idiotypes
• Ir gene control of the insulin-specific immune response in mice
• Influence of insulin modification upon the immune response to insulin
• Function and complementation of Ir genes controlling the responsiveness of mice to insulin
• The XID gene controls Ia.W39 associated immune response gene function for insulin induced T cell activation
• Induction of immunity and suppression by pig insulin in mice
• Genetic control of anti-insulin responses is associated with activation of different T-cell sets
• Suppression of insulin responses in vitro
• Immune response phenotype of insulin-presenting cells modified by insertion of H-2 gene products into cell membranes
• Differences in insulin antibodies induced with varying antigenic forms
• Mouse hybridoma antibody recognition of the insulin molecule
• SECTION II. CLINICAL ASPECTS OF IMMUNITY TO INSULIN
• Clinical aspects of immunity to insulin
• Antibody production during insulin therapy - patterns of response and clinical sequels
• Studies of the immunogenicity of chromatographically purified insulins in Type-I and Type-II diabetics
• Genetic control of the IgE response to insulin
• HLA-DR association of humoral immunoresponsiveness to insulin in insulin-dependent (Type I) diabetes mellitus
• Insulin antibody formation following conventional or monocomponent insulin treatment is influenced by genes of the HLA-DR locus
• A study of HLA alloantigen frequencies in insulin allergic and non-allergic diabetics
• Morphologic changes in pancreas islets after active or passive immunization against insulin: a review
• The role of autoimmune processes in the development of insulin-dependent diabetes mellitus in mice treated with streptozotocin
• Effect of insulin-binding antibodies of free insulin in plasma and tissue after subcutaneous injection. A model study
• Immunogenicity of insulin in relation to its physicochemical properties
• Potentation of insulin immunogenicity by different types of adjuvant
• Use of modified insulins for the separation of insulin antibodies by affinity chromatography
• The immunogenicity of insulin from our point of view
• SECTION III. CHEMISTRY TO INSULIN
• Preparation of insulins with modified N-terminals by semisynthesis and chemical modification of the native hormone
• Synthesis of insulin analogues
• Modification of the C-terminal region of insulin
• SUBJECT INDEX
• AUTHOR INDEX